Collects the finest work from throughout Crumb's career, ranging from some of the earliest published ocmics in the mid-sities to work completed in the nineties. His best stories, illustrations, covers, and paintings are here, many of them appearing in color for the first time.

Treats the history of comic books and displays one story by each of 22 artists: William M. Gaines, Will Eisner, Jack Kirby, Al Feldstein, Harvey Kurtzman, Stan Lee, Robert Crumb, Victor Moscoso, Spain, Gilbert Shelton, Dan O'Neill, Shary Feinniken, Bill Griffith, Harvey Pekar, Jamie Hernandez, Lynda Barry, Paul Mavrides, Francoise Mouly, Charles Burns, Sue Coe, Art Spiegelman, and Frank Miller.